interaction between drug dna for designing anticancer drugs studied in iran
Saturday 18 January 2025
Last Updated : GMT 09:40:38
Themuslimchronicle, themuslimchronicle

Interaction between drug, DNA for designing anticancer drugs studied in Iran

Themuslimchronicle, themuslimchronicle

Themuslimchronicle, themuslimchronicleInteraction between drug, DNA for designing anticancer drugs studied in Iran

Iranian researchers used nanoparticles
Tehran - FNA

- Iranian researchers used nanoparticles as quantum dots and presented a new, effective and sensitive method to study interaction between drug and DNA.

Data obtained from this method can be used in the designing of anticancer drugs.
Studying the interaction between drugs and DNA is important for designing more effective anticancer drugs and for better understanding of biological processes such as gene translation and DNA chain transcription. In this research, the mechanism of fluorescent resonance energy transfer (FRET) from drug to nanoparticle (quantum dot) has resulted in the creation of a highly sensitive method to study interaction between drug and DNA.
Dr. Somayyeh Gholami, a graduate in analytical chemistry from Institute for Advanced Studies in Basic Sciences in Zanjan, explained about the research, and said “Taking into account the shining and appropriate optical stability of quantum dots, FRET sensitive and powerful method was designed in this research to quantitatively study the interaction between actinomycin anticancer drug and genome double strand. The results showed that the predicted hybridation equivalent coefficient for the formation of drug-DNA compound was in acceptable agreement with laboratorial data, and it confirmed a strong bond between the drug and the double strand.”
“It must be pointed out that almost all the sequences related to four-strands are located at genome double strand zones. Therefore, the stability of DNA double strand or its combination with the drug can be considered a major limit for the formation of four-strands. In this study and by using an appropriate method and meaningful three dimensional data and using a powerful statistical method to analyze results, we succeeded in obtaining desirable information in this regard, which will be helpful in future studies in designing anticancer drugs,” she added.
Results of the research have been published in Analytical and Bioanalytical Chemistry, vol. 405, issue 19, July 2013, pp. 6271-6280.

 

themuslimchronicle
themuslimchronicle

Name *

E-mail *

Comment Title*

Comment *

: Characters Left

Mandatory *

Terms of use

Publishing Terms: Not to offend the author, or to persons or sanctities or attacking religions or divine self. And stay away from sectarian and racial incitement and insults.

I agree with the Terms of Use

Security Code*

interaction between drug dna for designing anticancer drugs studied in iran interaction between drug dna for designing anticancer drugs studied in iran

 



Themuslimchronicle, themuslimchronicle
Themuslimchronicle, themuslimchronicle
Themuslimchronicle, themuslimchronicle

GMT 19:51 2014 Monday ,31 March

Japan, North Korea agree to continue talks

GMT 14:25 2018 Sunday ,21 January

50,000 at Greek protest over Macedonia name row

GMT 07:53 2018 Monday ,15 January

Car bomb wounds Hamas official in south Lebanon

GMT 06:27 2017 Thursday ,12 October

France, Qatar neck-and-neck

GMT 10:23 2017 Friday ,15 December

Putin, Trump discuss North Korea in phone call

GMT 11:46 2017 Friday ,08 September

Sources deny rumors over Wasoof’s health

GMT 09:36 2017 Tuesday ,28 March

No word from Maradona over threat to quit

GMT 12:26 2016 Saturday ,01 October

Kvitova ends title drought with Wuhan win

GMT 15:31 2017 Thursday ,30 March

Arab Summit Concludes in Jordan

GMT 21:57 2016 Sunday ,30 October

Cibulkova Wins WTA Final in Singapore

GMT 14:12 2017 Wednesday ,06 December

Russian air strikes kill 21 civilians in east Syria

GMT 04:02 2016 Thursday ,08 December

Int'l cooperation minister in Amman for women conference

GMT 13:06 2017 Thursday ,09 February

Stresses Ahly ability to win super cup

GMT 01:33 2016 Wednesday ,17 August

British FTSE 100 drops 0.68% on Tuesday
Themuslimchronicle, themuslimchronicle
Themuslimchronicle, themuslimchronicle
 
 Themuslimchronicle Facebook,themuslimchronicle facebook  Themuslimchronicle Twitter,themuslimchronicle twitter Themuslimchronicle Rss,themuslimchronicle rss  Themuslimchronicle Youtube,themuslimchronicle youtube  Themuslimchronicle Youtube,themuslimchronicle youtube

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2023 ©

Maintained and developed by Arabs Today Group SAL.
All rights reserved to Arab Today Media Group 2023 ©

muslimchronicle muslimchronicle muslimchronicle muslimchronicle
themuslimchronicle themuslimchronicle themuslimchronicle
themuslimchronicle
بناية النخيل - رأس النبع _ خلف السفارة الفرنسية _بيروت - لبنان
themuslimchronicle, themuslimchronicle, themuslimchronicle