Six-time champions Boca Juniors were Friday drawn to play Paraguay's Cerro Porteno in the Copa Libertadores round of 16.
The Argentine outfit, who finished top of group 3 with 12 points from six matches, will travel to Asuncion on April 28 before the return match at their Bombenera stadium on May 5.
Cerro Porteno qualified for the knockout phase by finishing second in Group 8 with 10 points.
Meanwhile defending champions River Plate have been drawn against Ecuador's Independiente del Valle.
River, who topped Group 1 with 11 points, will travel to Quito for the first leg on April 28 with the return fixture at the Monumental on May 4.
Colombia's Atletico Mineiro, who finished the group phase with a competition-high 16 points, will meet Argentina's Huracan in Buenos Aires on April 26 and then in Medellin on May 3.
Three-time Copa Libertadores title winners Nacional of Uruguay will confront reigning Brazilian Serie A champions Corinthians at home on April 27 and away on May 4.
Copa Libertadores Round of 16
First leg:
April 26
19.30. Huracan vs. Atletico Nacional
21.45. Tachira vs. Pumas
April 27
19.30. Racing vs. Atletico Mineiro
21.45. Nacional vs. Corinthians
21.45. Gremio vs. Rosario Central
April 28
19.30. Independiente del Valle vs. River
21.45. Cerro Porteno vs. Boca
21.45. San Pablo vs. Toluca
Second leg:
May 3
21.45. Atletico Nacional vs. Huracan
23.45. Pumas vs. Tachira
May 4
19.15. River vs. Independiente del Valle
19.15. Toluca vs. San Pablo
21.45. Atletico Mineiro vs. Racing
21.45. Corinthians vs. Nacional
May 5
19.15. Rosario Central vs. Gremio
21.45. Boca vs. Cerro Porteno
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