Three astronauts landed safely in Kazakhstan after a flight from the International Space Station Sunday, including US astronaut Kate Rubins, the first person to sequence DNA in space.

Russian mission control confirmed the touchdown of NASA's Rubins, Roscosmos' Anatoly Ivanishin and Takuya Onishi of the Japan Aerospace Exploration Agency at 0958 GMT.

The trio landed southeast of the Kazakh steppe town of Zhezkazgan in frosty conditions following a 115-day mission aboard the orbital lab.