Campaigning drew to a close on Tuesday in Catalonia's regional election, a potential turning point in Spain's worst political crisis in decades.

The atypical campaign ended with deposed Catalan leader Carles Puigdemont holding a rally via videolink from exile in Belgium and another candidate rallying voters from behind bars in Spain.

Thursday's voting pits leaders of the wealthy northeastern region's separatist movement against candidates who want to stay part of a unified Spain.

Voters are highly mobilised and a record turnout is expected, but with pro- and anti-independence candidates neck-and-neck in opinion polls neither side is likely to win a clear majority.

The election is being closely watched across a European Union still reeling from Britain's shock decision to leave and wary about any breakup of the eurozone's fourth largest economy.

It has inflamed passions not just in Catalonia but across Spain, whose government took the unprecedented step of stripping the region of its autonomy after its parliament declared independence on October 27.

"This is not a normal election," Puigdemont told supporters in a final, virtual rally via videolink from self-imposed exile in Brussels.

"What is at stake is not who gets the most votes, but whether the country (Catalonia) or (Spanish Prime Minister Mariano) Rajoy wins" the standoff, he added.

- Independence on hold -

But with their camp in disarray, secessionists would likely put their independence drive on hold should they win Thursday's vote.

"Even if a pro-independence government is formed it will be very cautious how it acts because it won't want to lose the restored authority the Catalan government has," Andrew Dowling, contemporary historian in Hispanic studies at Cardiff University, told AFP.

"It won't want to see that suspended again," he added.

The deposed government's failed independence declaration saw more than 3,000 companies relocating from the region, and no country recognising the new "republic".

While opinion polls suggest a narrow lead for the leftist, pro-independence ERC, voters could ultimately hand victory to centrist party Ciudadanos, whose charismatic candidate Ines Arrimadas has campaigned on a fierce anti-nationalist ticket.

She is fighting to replace Puigdemont, who is wanted by the Spanish courts on charges of sedition, rebellion and misuse of public funds.

"We are very close to making our dream come true," Arrimadas told supporters at a rally Tuesday in a working-class district of Barcelona.

"We are going to wake up from this nightmare on Thursday," she added.

Miguel Carillo, 62, a longtime supporter of Rajoy's ruling conservative Popular Party (PP), said he would vote strategically this time for Ciudadanos.

"We don't want a republic," he said. "We want to be united with Spain."

The PP's loss of support led Rajoy to travel to Barcelona for the last few days of campaigning, in hope of rallying votes for his party.

"A vote for the PP is a vote for freedom, social peace, the law, harmony, the Spanish constitution, plurality, and in favour of Catalonia, Spain and Europe," he said.

- Worst crisis in decades -

In another surreal twist to the Catalan election campaign, Puigdemont's former deputy, Oriol Junqueras, has been campaigning from jail, with his ERC party running on its own ticket.

Now the separatists are not just fighting pro-unity parties for votes -- but each other.

Allowed just 10 phone calls a week from jail, Junqueras has led an unorthodox campaign, giving interviews to Catalan radio and sending articles, letters and even poems to supporters.

Junqueras's supporters gathered at the prison outside Madrid where he is being held to demand his release.

From there, they travelled to Junqueras's hometown near Barcelona, Sant Vicenc dels Horts, for a final rally.

The Catalan crisis came to a head on October 1, when the now deposed government held a banned referendum on independence.

The vote was marred by a brutal police crackdown and triggered Spain's worst political crisis in Spain in decades.

- Deadlock? -

Neither separatist nor pro-unity parties are predicted to win a decisive majority in the 135-seat parliament, which could lead to lengthy negotiations to form a regional government.

But separatists still appear to have a slight lead.

"Supporters of independence tend to vote more reliably, and the electoral system over-represents rural areas, where nationalist sentiment is strongest," said Ana Luis Andrade, Europe analyst at the Economist Intelligence Unit.

If parties cannot agree a governing coalition, Catalonia could face fresh elections next year, prolonging the political uncertainty.

Source: AFP