Champions League holders Real Madrid take on Tottenham Hotspur at Wembley on Wednesday with both teams looking to secure a place in the last 16.

Manchester City and Besiktas can also book their spots in the knockout stages, while Liverpool bid to put another hatful of goals past Maribor.

Here AFP Sport takes a look at what is at stake in each group (kick-offs 1945 GMT unless stated):

Group E

At Liverpool, England

Liverpool (ENG) v Maribor (SLO)

Jurgen Klopp's side sit top of the group after their record-breaking 7-0 thrashing of Maribor in Slovenia two weeks ago. Five different players scored as Liverpool chalked up the biggest away win for an English team in the history of the competition. The five-time European champions could seal a last-16 place with Anfield victories against Maribor and Spartak Moscow in their next two outings, having not reached the knockout phase since 2008-09. Liverpool grabbed a much-needed 3-0 win over Huddersfield Town in the Premier League on Saturday to bounce back from a 4-1 defeat by Tottenham. Defeat for Slovenian champions Maribor would see them eliminated if Sevilla lose to Spartak Moscow.

At Seville, Spain

Sevilla (ESP) v Spartak Moscow (RUS)

Record five-time Europa League winners Sevilla are in danger of missing out on the last 16 after a shock 5-1 thumping in Moscow last time out. Russian champions Spartak are level on points at the top of the standings with Liverpool, and a positive result in Spain would put them in a strong position with their next group match at home against struggling Maribor. Sevilla moved up to fifth in La Liga on Saturday by edging out Leganes 2-1 for their first win in three league games.

Group F

At Naples, Italy

Napoli (ITA) v Manchester City (ENG)

Maurizio Sarri's Italian league leaders extended their superb unbeaten start to the domestic campaign with a 3-1 win over Sassuolo -- the ninth time in 11 Serie A matches they've netted three or more goals. Like Napoli, Manchester City have dropped just two points in a flying start to their Premier League campaign, and a draw at the San Paolo would send Pep Guardiola's men through to the last 16 for the fifth consecutive year. City have kept eight clean sheets in their last 12 matches and are undefeated in 21 games dating back to last April. Sergio Aguero remains a goal away from becoming the club's outright all-time leading scorer -- he is currently level with Eric Brook on 177 goals.

At Kharkiv, Ukraine

Shakhtar Donetsk (UKR) v Feyenoord (NED)

The Ukrainians will aim to secure back-to-back wins over pointless Feyenoord and take a significant stride towards the next phase. Shakhtar are second in the group -- three points behind City, and three ahead of Napoli -- while Feyenoord will be knocked out unless they register a maiden win in Ukraine. Shakhtar defender Yaroslav Rakitskiy is banned after his sending-off in the 2-1 win in Rotterdam, while Dutch champions Feyenoord have fallen 10 points off the pace in the Netherlands after winning just once in six attempts.

Group G

At Istanbul, Turkey

Besiktas (TUR) v Monaco (FRA) (1700)

Victory for Besiktas would secure a ticket for the last 16 for the first time in 31 years. After three wins from their first three games, a win coupled with a draw between Porto and RB Leipzig would also confirm top spot for the Istanbul outfit. A draw could also take them through if RB Leipzig beat FC Porto. Monaco reached the semi-finals last season but sit bottom the group without a win and defeat would leave them on the brink of bowing out of the competition. Leonardo Jardim's principality outfit may also have to make do without unfit captain and star striker Radamel Falcao in Turkey. Besiktas won the reverse fixture 2-1 and have never lost at home to a French team in Europe.

At Porto, Portugal

Porto (POR) v RB Leipzig (GER)

Last season's Bundesliga runners-up revived their hopes of progressing from the group with a 3-2 win over Porto a fortnight ago and are one point clear of the Portuguese side in second. Champions League debutants Leipzig suffered two defeats to German title rivals Bayern Munich last week in the Cup and the league, while Porto maintained their two-point lead in Portugal by beating Boavista. The two-time European champions are looking to reach the last 16 for the third time in four seasons.

Source:AFP